Margaret Chappelear McDuffie was the daughter of Henry Chappelear who was the son of James Chappelear, who was the son of Isaac Jr.
I have not been able to find the parents of Murdoch McDuffie nor the county in NC where he was born. According to the census he was born in NC 1799. He was in Franklin Co., GA when he married Margaret Chappelear and their first child was born. They then moved to Cherokee Co., AL.
If you find anyone else working on this McDuffie bunch, please send them my way.
Most of what I know about the early Chappelears came from Nancy Chappelear Beard, her book and her father's book.