I'm related to the McGuire side of Irene's McGuire Manley's family. Her father, Thomas McGuire (m. to Mary McHale), is my great-grandfather Michael McGuire's brother. Their parents, my great-great-grandparents are Patrick and Ellen (aka Helen) McIntyre McGuire. Other children of Patrick & Ellen McIntyre McGuire besides Michael and Thomas are:
John McGuire (m. to Mary Ann Gillespie)
Patrick McGuire, Jr. (never married)
Denis McGuire (m. to Clara Westgate)
Mary Ellen McGuire Davitt (m. to Patrick Davitt)
Catherine ("Katie") McGuire Moran (m. to Patrick Moran)
Nora McGuire Cavanaugh (m. to Thomas Cavanaugh)
Irene is a first-cousin to my grandfather Harold (aka Michael Jr.) McGuire. My grandfather's mother, Theresa Burke, was married to Michael McGuire, Sr.