I am a descendent of John Kirkpatrick, one of the sons of Francis Kirkpatrick by his second wife Margaret and half-brother to your Samuel.
Samuel Kirkpatrick, who lived for a time in Jackson County TN, was a son of Francis Kirkpatrick by his first wife and was born ca 1772 in SC (probably Chester Co.) The following is from "A Kirkpatrick Genealogy" ed by Melvin E. Kirkpatrick and David Hudson:
"Samuel Kirkpatrick (Francis, James), was born in 1772 and was the youngest son of Francis Kirkpatrick's first marriage. His wife was Jane or Jean Steele. The pair were married circa 1800. Samuel was born in South Carolina but migrated to Jackson Couny, Tennessee. In about 1837 he moved to Scott County, Missouri, where he lived the remainder of his life. He died in Wayne County, Missouri, while visiting one of his sons. Jane (Steele) Kirkpatrick, Samuel's wife, died in 1848 in Scott County, Missouri. Day Jewell identifies four of Samuel's children. We find a fifth son.
Francis, James, Phillip, Wallace, Alfred b. 24 Jan. 1817."
For references the editors show:
Jewell, Captain Day. (U.S. Army ret.) "The Kirkpatricks", nd.
"History of Clay and Platte Counties, Missouri" (St. Louis: National Historical Co., 1885)
Paxton, William McClung, "Annals of Platte County, Missouri", (Kansas City: Hudson-Kimberly Publ. Co., 1897)
In addition to the Jackson Co TN censuses you probably already have, you will find Samuel enumerated with his son Francis Kirkpatrick in Scott Co MO in 1850. Unlike the above, my research shows he moved to MO after his sons did, and was enumerated in the 1840 census of Jackson Co TN. He also is mentioned in the biographical sketch of John Kirkpatrick in "Goodspeeds History of Southeast Missouri", A Reprint Edition (Cape Girarardeau MO: Ramfre Press, 1955.)
Francis Kirkpatrick, Samuel's father, was a Revolutionary War Patriot and you can find several indents for payments to him in South Carolina records. The name of his first wife is unknown and his second wife was named Margaret. His burial place is unknown, but he left a will dated 28 Apr 1791 and probated 28 Sep 1798 in Chester County.
James Kirkpatrick, Samuel's grandfather, was probably one of the Kirkpatrick brothers who immigrated from Scotland/Ireland and first settled along the Pennsylvania/New Jersey Colony line. He received four large land grants from the Governor of North Carolina in Anson County NC that ended up in South Carolina when the final boundry between the two Colonies was made. The grants are now in southern York and northern Chester Counties SC. He died 9 May 1786 and he and his wife Mary (d. 16 Sep 1769) were buried in the Old Irish Cemetery in Chester County. The cemetery is on private property and is now off limits due to the deteriorating condition of the cemetery and the presence of an Indian Mound nearby. He left a will dated 10 Mar 1786 which is filed in Kershaw County.
If researching the descendents of Samuel, take care not to confuse his son Wallace with his brother Wallace as "A Kirkpatrick Genealogy" had done. The son lived in Mississippi Co MO while the brother lived in St. Charles Co, MO.