I have been researching William Hoge and Barbara Hume for many years and they did have a son named James, but his birthdate is 1706, not 1680. It may just be a mistake. Is the James Hoge that you speak of the husband of Nancy Griffith and Agnes Crawford?
Also, if William Hoge was married twice, it was after the death of Barbara Hume, not before:
From, Pioneers of Old Frederick County, Virginia by Cecil O'Dell
"William Hoge, Sr. of Nottingham, Chester County, Pennsylvania dated his will on 17 April 1729, listing his wife Barbara and sons: John, William, Alexander, James and George. He also listed sons-in-law Neal Thomson and Robert White. He listed only one daughter, Joreter, indicating that his other daughter(s) may have died. George Hoge was appointed administrator of the estate on 15 November 1749. His wife Barbara must have died before him (after 20 October 1744) as it was his widow Mary Hoge who released all rights and title of dower in 203 acres of land to George Hoge, the administrator of the estate, for 40 shillings yearly. This release was recorded in Frederick County, Virginia on 15 November 1750."---Frederick Co., Virginia Deed Book 2, p. 202.
From, Hopewell Friends History 1734-1934 Frederick County, Virginia:
"William Hoge died before August 8, 1749. On that day his will was filed and recorded in the Frederick County clerk's office, but was not probated. His widow, Mary Hoge, declined accepting the provisions thereof, and claimed her dower."
Hope this helps!