Carol, I am not related to your family, but here are some of my thoughts. Most of them you already know.
Per the 1860 census of Masaac Co., Perry little (b. 1815) and wife Elizabeth (B. 1824) had the following Clark children: Camden ( a boy, b. 1846) and several other Clark children ending with Jacob Clark Ib. 1859). Based on these birth years, I estimate the parents of the Clark children married circa 1844-1845. And both parents died circa 1858-1860, maybe in an accident.
Looking over the Masaac Co marriages , a George Clark married Margaret Little 1/1845. Maybe they were the parents of the Clark children and Margaret maybe was the sister of Perry.
Maybe this can give some a couple new ideas on that family. Bob Eddings.